[Nichebabies] YOUR DETOX CENTRE NEEDS DETOXINGIs Year 2017 n Happy New Year! Tis the season for merriment and joy!As

YOUR DETOX CENTRE NEEDS DETOXING

Is Year 2017 n Happy New Year! Tis the season for merriment and joy!

As the food and drinks flow, take a moment to consider your hardworking liver. All the blood flow from the gastro-intestinal tract must flow to the liver before it passes through to the rest of the body. Not only does the liver receive food substances, it is also the first organ which gets hit by any toxin, chemical substances or inflammatory substances absorbed from the gut. That’s why our liver is indeed our body’s main detox centre.

But there is a limit to how much our liver can take. A sudden surge of toxin such as bingeing on alcohol can overwhelm the liver. Prolonged exposure to alcohol can slowly poison the liver too. The end result of liver injury is inflammation followed by fatty change in liver cells, cirrhosis and eventually, liver failure or even liver cancer.

While it is best to abstain from consuming alcohol, if it is impossible to avoid you should take steps to protect this vital organ from being injured by sudden binge drinking or prolonged drinking.

Alcohol injures the liver because it upsets the natural intestinal bacteria balance and results in a build-up of toxins produced by unhealthy intestinal bacteria. At the same time alcohol destroys the intestinal surface, allowing the toxins to easily cross over into the blood stream. The toxins go straight to the liver causing liver inflammation which progresses to fatty liver, cirrhosis and liver failure.

But there is an option available. LactoGG’s GG probiotic strain has been found to reduce liver injury due to alcohol.

How does LactoGG’s probiotic do it?

1. The “GG” probiotic breaks down the toxic end-product of alcohol called acetaldehyde.

2. It reduces inflammation of the stomach and intestinal surface caused by alcohol and promotes regeneration of injured intestinal cells. These protective effects help maintain a strong and intact intestinal surface barrier and prevent the absorption of toxins.

3. LactoGG’s probiotic bacteria in the gut promote the growth of many types of healthy bacteria despite the presence of alcohol. Having a wide variety of healthy intestinal bacteria is one of the keys to healthy intestinal function.

Because of LactoGG’s probiotic’s beneficial effects, studies have found that taking this probiotic before and after the consumption of alcohol has a direct anti-inflammatory effect on the liver. (Figure 1) If alcohol consumption has been going on over a long time, LactoGG’s probiotic REVERSES liver inflammation and fatty liver. During sudden consumption of large volumes of alcohol (binge drinking) LactoGG’s probiotic PREVENTS liver injury if the probiotic is taken before drinking. (Figure 2)

So when enjoying the festivities, spare a thought for your hardworking liver and take your friend, LactoGG, with you to the parties!

Reference:

Keshavarzian A et al. Leaky gut in alcoholic cirrhosis:a possible mechanism for alcohol-induced liver damage. Am J Gastroenterol 1999;94:200-207

Mutlu E et al. Intestinal dysbiosis: a possible mechanism of alcohol-indued endotoxemia and alcoholic setateohepatitis in rats. Alcohol Clin Exp REs 2009;33:1836-1846

Bode C et al. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J Hepatol 1987;4:8-14
Nosova T. Acetaldehyde production and metabolism by human indigenous and probiotic Lactobacillus and Bifidobacterium strains. Alcohol Alcohol 2000;35(6):561-568

Wang Y et al. Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury. Am J Pathol 2011;179:2866-2875

Donato KA et al. Lactobacillus rhamnosus GG attenuates interferon-ɣ and tumor necrosis factor-ɑ-induced barrier dysfunction and pro-inflammatory signalling. Microbiology 2010 July 23;doi:10.1099/mic.0.040139-0

Yan F et al. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth. Gastroenterology 2007;132:562-75

Lam EKY et al. Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG. Life Sciences 2007;80:2128-36

Forsyth CB et al. Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis. Alcohol 2009;43(2):163-172

Wang Y et al. Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury. Am J Physiol Gastrointest Liver Physiol 2012;doi:10.1152/aj[gi.00024.2012

Adawi D et al. Effects of different probiotic strains of Lactobacillus and Bifidobacterium on bacterial translocation and liver injury in an acute liver injury model. Int J Food Microbiol 2001;70:213-220

Nanji AA et al. Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease). Proc Soc Exp Biol Med 1994;205(3):243-247

Bajaj JS et al. Randomized clinical trial: lactobacillus gg modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis. Aliment Pharmacol Ther 2014;39(10):1113-25

Bull-Otterson L et al - Metagenomic Analyses of Alcohol Induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment. PLoS ONE 8(1):e53028.doi:10.1371/journal.pone.0053028


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Till 1 May 2017 Sheng Tai Toys: Branded Toys Warehouse Sale Up to 90% OFF Bandai, Takara Tomy & more!

Sheng Tai Toys: Branded Toys Warehouse Sale Up to 90% OFF Bandai, Takara Tomy & more!
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The annual Branded Toys Warehouse Sale is happening from today till 1 May 2017! Get toys from Bandai, Takara Tomy and more at up to 90% off. Present the below flyer to redeem a free gift!

 

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Book by 16 May 2017 Cathay Pacific: Special Premium Economy and Economy Class Fares from SGD188 with Maybank Cards

Cathay Pacific: Special Premium Economy and Economy Class Fares from SGD188 with Maybank Cards
Local Posted 2 days ago

Plan your vacation now to Bangkok, Hong Kong, China, Taiwan, Korea, Japan, Europe, Middle East and North America. Grab Cathay Pacific's special offers from SGD188 all-in with Maybank Cards. Offer ends 16 May 2017.

 

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28 - 30 Apr 2017 Le Creuset: Family Sale with Up to 70% OFF Cookware

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Local Posted 2 days ago

It’s finally here! Head to the Le Creuset Family Sale for the best deals in town! Enjoy up to 70% off their cookware at this sale from 28 to 30 April 2017!

For this sale, they will release a SURPRISE BUY item every day in limited quality only (first come first serve, while stocks last!). Follow their FB to be informed on the item every night!

 

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28 Apr - 1 May 2017 Metro: Special 1-for-1 Buys on Labour Day Long Weekend!

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Say “YES” to another long weekend! Enjoy special one-for-one buys this Labour Day at Metro from 28 Apr-1 May! Rather stay at home this long weekend? Shop in the comfort of your home this Labour Day on Metro.com.sg from now till 1 May!

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28 Apr - 1 May 2017 World of Sports: Mega Sports Expo Sale with Up to 90% OFF Footwear, Apparels, Sports Equipment & More

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THE MEGA SPORTS SALE YOU'VE BEEN WAITING FOR!!!

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Snatch them up before they are gone!
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1 May 2017 Gelare Café: Celebrate Labour Day with FREE Banana Ice Cream!

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28 Apr - 1 May 2017 EuropAce: Warehouse Sale with Up to 80% OFF Home Appliances

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Come and shop at EuropAce Warehouse Sale this long weekend! Their wide range of home appliances are going on sale with MASSIVE discounts! Up to 80% OFF! NTUC Members, flash your ntuc card to enjoy exclusive deals. See you there!

 

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26 Apr 2017 BQ’s Daily Top Deals: New Balance Pre Renovation Sale, Metro Travel Fair, Goldlion Warehouse Sale, Le Creuset Family Sale, Charcoal Thai 50% OFF Ala Carte Dishes & More!

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Book by 30 Apr 2017 Citi Cards: Enjoy 12% OFF Last Minute Getaway Exclusive Fares to 20 selected destinations on Emirates!

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Enjoy 12% off on Economy Class saver fares to 20 selected destinations with Citibank's exclusive 7 day offer for Citi Cardmembers.

Fly to other exciting places and save up to 10% on Flex and Flex Plus fare, or a 5% saving* on Saver fares in Business Class and Economy Class. Book using promo code and travel in May to enjoy greater savings. Offer is valid till 30 April 2017 for travel period between 1 – 31 May 2017.

*T&Cs apply.
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28 Apr - 1 May 2017 New Balance: Pre-Renovation Sale with $70 – $90 Star Buys & 20% OFF Storewide

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Show your brand love! Shop for New Balance sneakers & apparels on sale! Enjoy the best for less with New Balance Star Buys and 20% OFF storewide offer!

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27 - 30 Apr 2017 Goldlion: Warehouse Sale Up to 90% OFF + Additional 10% OFF on 3 Items & More!

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Check out Goldlion Warehouse Sale happening today! For a limited time period only, you get to enjoy up to 90% off on Goldlion products. Hurry and grab your friends, families and colleagues for a shopping spree this week!

For their FB Fans only, grab their special offer of additional 10% off on 3 items or more!

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Till 1 May 2017 OG Singapore: Enjoy 20% OFF Storewide Including Prestige Brand Cosmetics this Labour Day Weekend!

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Here's a great treat for the Labour Day long weekend!

Enjoy 20% off storewide on most brands regular-priced items from now till 1 May 2017 at OG. PLUS, you can also save on prestige brand cosmetics on Sat 29 Apr and Sun 30 Apr!

T&Cs apply.

 

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Daily till 30 Apr 2017 Qoo10: $3, $20 & $100 Cart Coupons Up for Grabs & Deals on Philips 4k Smart TV, Mavic Pro, Samantha Thavasa Wallets & More!

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From today till 30 April 2017, grab a $3, $20 and $100 cart coupon at Qoo10 to save on your purchases!

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28 Apr - 1 May 2017 Harvey Norman: Tech Expo 2017 with Never Before Marked Down Prices!

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Never before, MARKED DOWN prices at Harvey Norman Tech Expo 2017! You know where to go this long weekend.

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27 - 28 Apr 2017 Guardian: 2-Day Online Special Coupon Code for Additional 10% OFF

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Time to replenish your toiletries, health supplements or beauty products! Enjoy additional 10% DISCOUNT online at Guardian from 27 to 28 April 2017!

Head over to their e-store with the promo code and start SAVING!

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Till 10 May 2017 Metro: The Metro Travel Fair with 20% OFF Regular-Priced Items & Up to 60% OFF Sales Items

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Getting ready to travel? Prep for the upcoming school holiday in June with travel necessities featured in the Metro Travel Fair!

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